Scientific Advancements in Aging & Longevity Research

Older adults living with several chronic diseases, a condition known as multimorbidity, may respond differently to interventions aimed at preventing disability, depending on the combination of diseases they have. A new study, published in Nature Aging and led by researchers at Karolinska Institutet and Università Cattolica del Sacro Cuore in…

We tend to think of age as a linear progression marked by birthdays and milestones dictating when we can vote, drink, rent a car or pass beyond the crest of an arbitrary metaphorical hill. When scientists look at how organs age, however, it doesn't match the idea that we gradually…

Memory loss is usually thought of as something to address as a person ages. Slip-ups like forgetting someone's name or recognizing a familiar face but not remembering where you know them from are often viewed as issues that arise later in life. New research by a team at Binghamton University…

More walkable neighborhoods in New York City were associated with a lower risk of developing postpartum type 2 diabetes among women who had gestational diabetes mellitus (GDM), according to a new study from Columbia University Mailman School of Public Health. However, the association varied depending on individual and neighborhood socioeconomic…

The secret to a long life may lie in the genomes of the longest-lived mammals for their size: bats. That idea captivated Juan Manuel Vazquez when he was a graduate student at the University of Chicago, but at the time he couldn't find any good published information on bat genomes…

Statins are commonly prescribed to manage high cholesterol in people up to age 75 and are known to reduce the risk of heart attack and stroke.

Nature Aging, Published online: 28 August 2026; doi:10.1038/s43587-026-01214-yClosing the gap in Alzheimer’s disease research through the Sex | Gender in Neurodegeneration Consortium

Immunotherapies such as CAR T-cell therapy are used primarily to treat cancer. In the future, these patient-specific therapies, manufactured from patients' own immune cells, could also help cure autoimmune diseases. Six patients with particularly severe rheumatoid arthritis have now received this treatment at Charité—Universitätsmedizin Berlin. In the journal Nature Medicine,…

It is commonly perceived that multitasking is highly inefficient, with the brain often "crashing" or scrambling when trying to do two things at once. A recent study by City University of Hong Kong (CityUHK) has uncovered the mechanism behind this, revealing how the brain dynamically reorganizes itself to break through…

Shingles is a painful and serious condition affecting many older people. It is caused by the herpes zoster virus, which can flare up in people who previously had chickenpox. A vaccine against shingles (Zostavax) was introduced in 2006. In many countries, including the U.K. and U.S., Zostavax has now been…

For more than two decades, researchers have identified hundreds of genes that increase the risk of autism spectrum disorder (ASD). Yet multiple fundamental questions have remained unanswered: Among them, how do mutations in these genes lead directly to changes in brain development, and how can that knowledge be translated into…

Researchers have issued tailored advice for drivers with obstructive sleep apnea (OSA) after finding that common guidance for tackling tiredness behind the wheel may not be the most effective approach for people with the condition.

Forever chemicals have been linked to preterm births, miscarriage, preeclampsia and lower birth weights. Now, a first-of-its-kind study published in Environmental Science & Technology may offer clues about why. UC San Francisco Associate Professor Joshua Robinson, Ph.D., of the Department of Obstetrics, Gynecology and Reproductive Sciences, and colleagues conducted what…

A diet that severely limits carbohydrates but is high in fat has the greatest health benefits for people with obesity compared with a Mediterranean diet or a low-fat diet, according to a clinical trial published Aug. 27 in the journal Cell Metabolism. After following a ketogenic (or "Keto") diet for…

A new approach to caring for people experiencing a mental health crisis, emphasizing continuity and community, can reduce hospital admissions and improve satisfaction with care, a study led by a University College London (UCL) researcher found.

Breast cancer is often classified as either estrogen receptor-positive (hormone-sensitive) or not. However, a new study from Karolinska Institutet suggests that this simplified classification may overlook important biological differences between patients that could affect treatment decisions. The results are published in The Lancet Regional Health – Europe.

Social media use is a better predictor of depression than many other common factors, such as one's job and educational background or time spent on other activities, such as playing video games, surfing the web or watching TV.

Researchers at the University of Maryland School of Medicine (UMSOM) have developed and validated a new risk calculator that can estimate an individual patient's short-term risk of developing a range of diabetes-related complications, using information already collected during routine medical care. The findings are published in the journal Nature Communications.

Adults with at least one parent who reached age 100 lived longer and had substantially lower risks of cardiovascular disease and hypertension than people whose parents had shorter lifespans, according to a study published today in JAMA Network Open.

New study suggests a lesser-known compound in tomatoes may help protect against fatty liver disease, which affects more than 1 in 3 American adults

A new study has identified why many men struggle with weight loss, finding that traditional diet programs are often perceived as too restrictive and primarily aimed at women. The research, published in PLOS One and led by Anglia Ruskin University (ARU) in England, is the first academic study to investigate…

Every three to five days, the layer of cells lining our intestines is completely renewed—the fastest turnover rate in the human body. Such rapid regeneration is an absolute necessity for tissue that endures constant mechanical stress as well as an abundance of bacteria and contaminants. But what happens to the…

University of Alberta researchers have discovered a novel drug that unlocks the secret of snail hibernation, allowing them to safely put non-hibernating animal organs into a deep metabolic sleep. The study, published in Nature Communications, is led by Dr. Evangelos Michelakis, professor in the Faculty of Medicine & Dentistry and…

Poor sleep quality has been linked to cognitive decline, neurodegeneration and Alzheimer's disease in older adults. A new international study led by Concordia researchers and published in the journal Neurology shows that specific sleep brain waves provide protection against the harmful effects of a brain chemical usually associated with wakefulness…

Nature Aging, Published online: 25 August 2026; doi:10.1038/s43587-026-01181-4Interrogating the role of the microbiome in aging, here the authors utilize multi-omics human cohort data to show that the abundance of Bifidobacterium pseudocatenulatum and its metabolite 5-aminovaleric acid betaine declines with age. Mouse studies confirm that both reduce inflammaging and extend healthspan.

Nature Aging, Published online: 25 August 2026; doi:10.1038/s43587-026-01180-5Aging is heterogenous, influenced by various factors, including biological sex. Here, leveraging a large-scale human aging phenome, the authors develop sex-stratified biological clocks to interrogate aging transitions, and uncover systemic metabolic and tumor marker signatures as features of aging.

Not all physical activity is equal when it comes to protecting the brain from dementia. Where and why we move may matter more than most people realize.

When Raghav Sehgal arrived at Yale as a graduate student several years ago, he wanted to explore the use of powerful computer science tools in cancer research. With an engineering background and a computational biology startup already under his belt, he was well prepared.

Research from the University of East Anglia shows how our memories change with age and why specific details associated with past events can fade over time. The new study reveals that as people age, they not only remember fewer details from their past—but also struggle more when switching between different…

When people of different generations create art together, their brains initially show more synchrony, and the synchrony can predict feelings of loneliness or social connection, according to a study published Aug. 20 in the journal PLOS Biology by Ryssa Moffat from ETH Zurich in Switzerland and colleagues.

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